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Research Article

Targeting the Oncogenic E3 Ligase Skp2 in Prostate and Breast Cancer Cells with a Novel Energy Restriction-Mimetic Agent

  • Shuo Wei,

    Affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

    Current address: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Po-Chen Chu,

    Affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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  • Hsiao-Ching Chuang,

    Affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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  • Wen-Chun Hung,

    Affiliation: National Institute of Cancer Research, National Health Research Institute, Zhunan, Miaoli County, Taiwan

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  • Samuel K. Kulp,

    Affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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  • Ching-Shih Chen mail

    chen.844@osu.edu

    Affiliations: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America, Institute of Basic Medical Sciences, National Cheng-Kung University, Tainan, Taiwan

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  • Published: October 12, 2012
  • DOI: 10.1371/journal.pone.0047298

About the Authors

Shuo Wei, Po-Chen Chu, Hsiao-Ching Chuang, Samuel K. Kulp, Ching-Shih Chen
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
Wen-Chun Hung
National Institute of Cancer Research, National Health Research Institute, Zhunan, Miaoli County, Taiwan
Ching-Shih Chen
Institute of Basic Medical Sciences, National Cheng-Kung University, Tainan, Taiwan

Corresponding Author

Email: chen.844@osu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SW CSC. Performed the experiments: SW PCC HCC. Analyzed the data: SW PCC HCC CSC. Contributed reagents/materials/analysis tools: WCH. Wrote the paper: SW SKK CSC.