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Research Article

Interleukin-33 Primes Mast Cells for Activation by IgG Immune Complexes

  • Shinjiro Kaieda equal contributor,

    equal contributor Contributed equally to this work with: Shinjiro Kaieda, Jun-Xia Wang

    Affiliation: Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jun-Xia Wang equal contributor,

    equal contributor Contributed equally to this work with: Shinjiro Kaieda, Jun-Xia Wang

    Affiliation: Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ruslan Shnayder,

    Affiliation: Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Nadia Fishgal,

    Affiliation: Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Hillary Hei,

    Affiliation: Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Richard T. Lee,

    Affiliation: Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Richard L. Stevens,

    Affiliation: Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Peter A. Nigrovic mail

    pnigrovic@partners.org

    Affiliations: Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0047252

About the Authors

Shinjiro Kaieda, Jun-Xia Wang, Ruslan Shnayder, Nadia Fishgal, Richard L. Stevens, Peter A. Nigrovic
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Hillary Hei, Richard T. Lee
Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Peter A. Nigrovic
Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: pnigrovic@partners.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SK JXW PAN. Performed the experiments: SK JXW RS NF HH PAN. Analyzed the data: SK JXW RLS PAN. Contributed reagents/materials/analysis tools: RTL. Wrote the paper: SK JXW PAN.