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Research Article

Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

  • Yukari Ido-Kitamura,

    Affiliations: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan, Department of Internal Medicine, Fujisawa Shounandai Hospital, Fujisawa, Kanagawa, Japan

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  • Tsutomu Sasaki,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Masaki Kobayashi,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Hye-Jin Kim,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Yong-Soo Lee,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Osamu Kikuchi,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Hiromi Yokota-Hashimoto,

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Katsumi Iizuka,

    Affiliation: Division of Molecule and Structure, Department of Diabetes and Endocrinology, Gifu University School of Medicine, Gifu, Gifu, Japan

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  • Domenico Accili,

    Affiliation: Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, United States of America

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  • Tadahiro Kitamura mail

    kitamura@gunma-u.ac.jp

    Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047231

About the Authors

Yukari Ido-Kitamura, Tsutomu Sasaki, Masaki Kobayashi, Hye-Jin Kim, Yong-Soo Lee, Osamu Kikuchi, Hiromi Yokota-Hashimoto, Tadahiro Kitamura
Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan
Katsumi Iizuka
Division of Molecule and Structure, Department of Diabetes and Endocrinology, Gifu University School of Medicine, Gifu, Gifu, Japan
Domenico Accili
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, United States of America
Yukari Ido-Kitamura
Department of Internal Medicine, Fujisawa Shounandai Hospital, Fujisawa, Kanagawa, Japan

Corresponding Author

Email: kitamura@gunma-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YI-K TK. Performed the experiments: YI-K TS MK H-JK Y-SL OK HY-H KI. Analyzed the data: YI-K TS MK DA TK. Contributed reagents/materials/analysis tools: YI-K TS MK HY-H KI. Wrote the paper: DA TK.