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Research Article

Activation of Haem-Oxidized Soluble Guanylyl Cyclase with BAY 60-2770 in Human Platelets Lead to Overstimulation of the Cyclic GMP Signaling Pathway

  • Camila B. Mendes-Silverio,

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Luiz O. S. Leiria,

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Rafael P. Morganti,

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Gabriel F. Anhê,

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Sisi Marcondes,

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Fabíola Z. Mónica,

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Gilberto De Nucci,

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Edson Antunes mail

    edson.antunes@uol.com.br

    Affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0047223

About the Authors

Camila B. Mendes-Silverio, Luiz O. S. Leiria, Rafael P. Morganti, Gabriel F. Anhê, Sisi Marcondes, Fabíola Z. Mónica, Gilberto De Nucci, Edson Antunes
Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

Corresponding Author

Email: edson.antunes@uol.com.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CBMS LOSL RPM GFA EA. Performed the experiments: CBMS LOSL GFA. Analyzed the data: CBMS LOSL RPM GFA EA FZM GDN SM. Wrote the paper: CBMS FZM EA.