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Research Article

Activation of AMP-Activated Protein Kinase by 3,3′-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and In Vivo

  • Di Chen,

    Affiliation: Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Sanjeev Banerjee,

    Affiliation: Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Qiuzhi C. Cui,

    Affiliation: Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Dejuan Kong,

    Affiliation: Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Fazlul H. Sarkar mail,

    doup@karmanos.org (QPD); fsarkar@med.wayne.edu (FHS)

    Affiliations: Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America, Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Q. Ping Dou mail

    doup@karmanos.org (QPD); fsarkar@med.wayne.edu (FHS)

    Affiliations: Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America, Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047186

About the Authors

Di Chen, Qiuzhi C. Cui, Fazlul H. Sarkar, Q. Ping Dou
Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
Sanjeev Banerjee, Dejuan Kong, Fazlul H. Sarkar, Q. Ping Dou
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QPD FHS DC. Performed the experiments: QCC SB DK DC. Contributed reagents/materials/analysis tools: DC QCC SB DK. Wrote the paper: DC.