Advertisement
Research Article

NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific Expression of Human γ-Globin Gene

  • Xingguo Zhu,

    Affiliation: Department of Biochemistry and Molecular Biology, Medical College of Georgia and College of Graduate Studies, Georgia Health Sciences University, Augusta, Georgia, United States of America

    X
  • Yongchao Wang,

    Affiliation: Department of Biochemistry and Molecular Biology, Medical College of Georgia and College of Graduate Studies, Georgia Health Sciences University, Augusta, Georgia, United States of America

    X
  • Wenhu Pi,

    Affiliation: Department of Biochemistry and Molecular Biology, Medical College of Georgia and College of Graduate Studies, Georgia Health Sciences University, Augusta, Georgia, United States of America

    X
  • Hui Liu,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

    X
  • Amittha Wickrema,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

    X
  • Dorothy Tuan mail

    dtuanlo@georgiahealth.edu

    Affiliation: Department of Biochemistry and Molecular Biology, Medical College of Georgia and College of Graduate Studies, Georgia Health Sciences University, Augusta, Georgia, United States of America

    X
  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047175

About the Authors

Xingguo Zhu, Yongchao Wang, Wenhu Pi, Dorothy Tuan
Department of Biochemistry and Molecular Biology, Medical College of Georgia and College of Graduate Studies, Georgia Health Sciences University, Augusta, Georgia, United States of America
Hui Liu, Amittha Wickrema
Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: dtuanlo@georgiahealth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XZ DT AW. Performed the experiments: XZ YW WP. Analyzed the data: XZ YW DT AW. Contributed reagents/materials/analysis tools: HL AW. Wrote the paper: XZ DT.