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Research Article

Global Changes in the Rat Heart Proteome Induced by Prolonged Morphine Treatment and Withdrawal

  • Zdenka Drastichova,

    Affiliation: Department of Physiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic

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  • Jitka Skrabalova,

    Affiliation: Department of Physiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic

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  • Petr Jedelsky,

    Affiliation: Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic

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  • Jan Neckar,

    Affiliation: Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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  • Frantisek Kolar,

    Affiliation: Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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  • Jiri Novotny mail

    novotnj99@natur.cuni.cz

    Affiliation: Department of Physiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047167

About the Authors

Zdenka Drastichova, Jitka Skrabalova, Jiri Novotny
Department of Physiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
Petr Jedelsky
Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
Jan Neckar, Frantisek Kolar
Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Corresponding Author

Email: novotnj99@natur.cuni.cz

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: J. Novotny ZD. Performed the experiments: ZD JS J. Neckar. Analyzed the data: ZD JS PJ. Wrote the paper: ZD FK J. Novotny.