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Research Article

Plaque Rupture Complications in Murine Atherosclerotic Vein Grafts Can Be Prevented by TIMP-1 Overexpression

  • Margreet R. de Vries,

    Affiliations: Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

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  • Hans W. M. Niessen,

    Affiliation: Department of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands

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  • Clemens W. G. M. Löwik,

    Affiliation: Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands

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  • Jaap F. Hamming,

    Affiliation: Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

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  • J. Wouter Jukema,

    Affiliations: Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Paul H. A. Quax mail

    p.h.a.quax@lumc.nl

    Affiliations: Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0047134

About the Authors

Margreet R. de Vries, J. Wouter Jukema, Paul H. A. Quax
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Margreet R. de Vries, Jaap F. Hamming, Paul H. A. Quax
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Hans W. M. Niessen
Department of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands
Clemens W. G. M. Löwik
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
J. Wouter Jukema
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

Corresponding Author

Email: p.h.a.quax@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MRdV HWMN JFJ PHAQ. Performed the experiments: MRdV HWMN. Analyzed the data: MRdV HWMN. Contributed reagents/materials/analysis tools: MRdV CWGML PHAQ. Wrote the paper: MRdV HWMN JFH JWJ PPHAQ.