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Research Article

Absence of Foxp3+ Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation

  • Abdul Mannan Baru,

    Affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Venkateswaran Ganesh,

    Affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Jayendra Kumar Krishnaswamy,

    Affiliation: Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany

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  • Christina Hesse,

    Affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Christopher Untucht,

    Affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Silke Glage,

    Affiliation: Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany

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  • Georg Behrens,

    Affiliation: Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany

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  • Christian Thomas Mayer,

    Affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Franz Puttur,

    Affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Tim Sparwasser mail

    Tim.Sparwasser@twincore.de

    Affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047102

About the Authors

Abdul Mannan Baru, Venkateswaran Ganesh, Christina Hesse, Christopher Untucht, Christian Thomas Mayer, Franz Puttur, Tim Sparwasser
Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany
Jayendra Kumar Krishnaswamy, Georg Behrens
Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
Silke Glage
Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany

Corresponding Author

Email: Tim.Sparwasser@twincore.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AMB TS. Performed the experiments: AMB VG JKK CH CU FP. Analyzed the data: AMB VG JKK CH CU SG. Contributed reagents/materials/analysis tools: JKK GB. Wrote the paper: AMB CTM TS.