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Research Article

In Vitro Functional Analyses of Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Desmoglein-2-Missense Variations

  • Anna Gaertner,

    Affiliation: Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic of Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany

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  • Baerbel Klauke,

    Affiliation: Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic of Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany

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  • Ines Stork,

    Affiliation: Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic of Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany

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  • Karsten Niehaus,

    Affiliation: Department for Proteome and Metabolome Research, Faculty of Biology and Centre for Biotechnology-CeBiTec, Bielefeld University, Bielefeld, Germany

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  • Gesa Niemann,

    Affiliation: Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany

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  • Jan Gummert,

    Affiliation: Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic of Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany

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  • Hendrik Milting mail

    hmilting@hdz-nrw.de

    Affiliation: Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic of Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047097

About the Authors

Anna Gaertner, Baerbel Klauke, Ines Stork, Jan Gummert, Hendrik Milting
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic of Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany
Karsten Niehaus
Department for Proteome and Metabolome Research, Faculty of Biology and Centre for Biotechnology-CeBiTec, Bielefeld University, Bielefeld, Germany
Gesa Niemann
Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany

Corresponding Author

Email: hmilting@hdz-nrw.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AG BK IS HM. Performed the experiments: AG GN KN. Analyzed the data: AG BK HM. Contributed reagents/materials/analysis tools: GN KN JG HM. Wrote the paper: AG HM.