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Research Article

An RNA Interference Lethality Screen of the Human Druggable Genome to Identify Molecular Vulnerabilities in Epithelial Ovarian Cancer

  • Geetika Sethi equal contributor,

    equal contributor Contributed equally to this work with: Geetika Sethi, Harsh B. Pathak

    Affiliations: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America, Department of Biochemistry, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Harsh B. Pathak equal contributor,

    equal contributor Contributed equally to this work with: Geetika Sethi, Harsh B. Pathak

    Affiliations: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America, University of Kansas Cancer Center, Kansas City, Kansas, United States of America

    X
  • Hong Zhang,

    Affiliation: Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

    X
  • Yan Zhou,

    Affiliation: Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

    X
  • Margret B. Einarson,

    Affiliation: Translational Core Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

    X
  • Vinod Vathipadiekal,

    Affiliation: Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Sumedha Gunewardena,

    Affiliation: Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

    X
  • Michael J. Birrer,

    Affiliation: Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Andrew K. Godwin mail

    agodwin@kumc.edu

    Affiliations: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America, University of Kansas Cancer Center, Kansas City, Kansas, United States of America

    X
  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047086

About the Authors

Geetika Sethi, Harsh B. Pathak, Andrew K. Godwin
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Geetika Sethi
Department of Biochemistry, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
Harsh B. Pathak, Andrew K. Godwin
University of Kansas Cancer Center, Kansas City, Kansas, United States of America
Hong Zhang
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Yan Zhou
Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Margret B. Einarson
Translational Core Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Vinod Vathipadiekal, Michael J. Birrer
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Sumedha Gunewardena
Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Corresponding Author

Email: agodwin@kumc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AKG GS HBP HZ. Performed the experiments: GS HBP HZ. Analyzed the data: AKG GS HBP YZ VV. Contributed reagents/materials/analysis tools: AKG GS HBP MBE MJB VV SG. Wrote the paper: AKG GS HBP YZ VV MBE.