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Research Article

Increased T Regulatory Cells Are Associated with Adverse Clinical Features and Predict Progression in Multiple Myeloma

  • Karthick Raja Muthu Raja mail,

    rajakarthick594@gmail.com

    Affiliations: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic

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  • Lucie Rihova,

    Affiliations: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Department of Clinical Hematology, University Hospital, Brno, Czech Republic

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  • Lenka Zahradova,

    Affiliation: Hemato-oncology, Department of Internal Medicine, University Hospital, Brno, Czech Republic

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  • Maria Klincova,

    Affiliation: Hemato-oncology, Department of Internal Medicine, University Hospital, Brno, Czech Republic

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  • Miroslav Penka,

    Affiliation: Department of Clinical Hematology, University Hospital, Brno, Czech Republic

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  • Roman Hajek

    Affiliations: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic, Department of Clinical Hematology, University Hospital, Brno, Czech Republic, Hemato-oncology, Department of Internal Medicine, University Hospital, Brno, Czech Republic

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047077

About the Authors

Karthick Raja Muthu Raja, Lucie Rihova, Roman Hajek
Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Karthick Raja Muthu Raja, Roman Hajek
Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
Lucie Rihova, Miroslav Penka, Roman Hajek
Department of Clinical Hematology, University Hospital, Brno, Czech Republic
Lenka Zahradova, Maria Klincova, Roman Hajek
Hemato-oncology, Department of Internal Medicine, University Hospital, Brno, Czech Republic

Corresponding Author

Email: rajakarthick594@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KRMR MP RH. Performed the experiments: KRMR LR MK LZ. Analyzed the data: KRMR LR LZ. Contributed reagents/materials/analysis tools: KRMR MK LZ MP RH. Wrote the paper: KRMR MP RH.