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Research Article

Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer

  • Shanna K. Nifoussi equal contributor,

    equal contributor Contributed equally to this work with: Shanna K. Nifoussi, Julie A. Vrana

    Affiliations: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States of America

    X
  • Julie A. Vrana equal contributor,

    equal contributor Contributed equally to this work with: Shanna K. Nifoussi, Julie A. Vrana

    Current address: Immunostains Laboratory, Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Aaron M. Domina,
  • Alfredo De Biasio,
  • Jingang Gui,
  • Mark A. Gregory,
  • Stephen R. Hann,

    Affiliation: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Ruth W. Craig mail

    Ruth.W.Craig@Dartmouth.edu

    Affiliations: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States of America

    X
  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047060

About the Authors

Shanna K. Nifoussi, Ruth W. Craig
Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
Shanna K. Nifoussi, Ruth W. Craig
Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States of America
Stephen R. Hann
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Corresponding Author

Email: Ruth.W.Craig@Dartmouth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SKN JAV AMD RWC. Performed the experiments: SKN JAV AMD. Analyzed the data: SKN JAV RWC. Contributed reagents/materials/analysis tools: SKN JAV AMD AD RWC. Wrote the paper: SKN JG RWC. Performed initial phospho-peptide mapping of Mcl-1 that lead to the development of phosphor-site specific mutants: MAG SRH.