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Research Article

Vitamin C Prevents Hypogonadal Bone Loss

  • Ling-Ling Zhu,

    Affiliations: School of Stomatology, Wuhan University, Wuhan, Hubei, China, The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Jay Cao,

    Affiliation: Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Grand Forks, North Dakota, United States of America

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  • Merry Sun,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Tony Yuen,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Raymond Zhou,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Jianhua Li,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Yuanzhen Peng,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Surinder S. Moonga,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Lida Guo,

    Affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Jeffrey I. Mechanick,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Jameel Iqbal,

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Liu Peng,

    Affiliation: School of Stomatology, Wuhan University, Wuhan, Hubei, China

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  • Harry C. Blair,

    Affiliation: Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Zhuan Bian mail,

    mone.zaidi@mssm.edu (MZ); kqyywjtx@hotmail.com (ZB)

    Affiliation: School of Stomatology, Wuhan University, Wuhan, Hubei, China

    X
  • Mone Zaidi mail

    mone.zaidi@mssm.edu (MZ); kqyywjtx@hotmail.com (ZB)

    Affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America

    X
  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047058

About the Authors

Ling-Ling Zhu, Liu Peng, Zhuan Bian
School of Stomatology, Wuhan University, Wuhan, Hubei, China
Ling-Ling Zhu, Merry Sun, Tony Yuen, Raymond Zhou, Jianhua Li, Yuanzhen Peng, Surinder S. Moonga, Jeffrey I. Mechanick, Jameel Iqbal, Mone Zaidi
The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, United States of America
Jay Cao
Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Grand Forks, North Dakota, United States of America
Lida Guo, Harry C. Blair
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LP HCB MZ. Performed the experiments: LZ JC MS RZ JL YP SSM. Analyzed the data: LZ TY LG JIM JI . Contributed reagents/materials/analysis tools: LP HCB MZ. Wrote the paper: ZB MZ.