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Research Article

Identification of an Annonaceous Acetogenin Mimetic, AA005, as an AMPK Activator and Autophagy Inducer in Colon Cancer Cells

  • Yong-Qiang Liu equal contributor,

    equal contributor Contributed equally to this work with: Yong-Qiang Liu, Xin Cheng

    Affiliations: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, Graduate University of the Chinese Academy of Sciences, Beijing, China

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  • Xin Cheng equal contributor,

    equal contributor Contributed equally to this work with: Yong-Qiang Liu, Xin Cheng

    Affiliation: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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  • Liang-Xia Guo,

    Affiliation: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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  • Chan Mao,

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Yi-Jie Chen,

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Hai-Xia Liu,

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Qi-Cai Xiao,

    Affiliation: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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  • Sheng Jiang,

    Affiliation: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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  • Zhu-Jun Yao mail,

    gbzhou@ioz.ac.cn (GBZ); yaoz@nju.edu.cn (YQL)

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Guang-Biao Zhou mail

    gbzhou@ioz.ac.cn (GBZ); yaoz@nju.edu.cn (YQL)

    Affiliation: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047049

About the Authors

Yong-Qiang Liu, Xin Cheng, Liang-Xia Guo, Guang-Biao Zhou
Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Yong-Qiang Liu
Graduate University of the Chinese Academy of Sciences, Beijing, China
Chan Mao, Yi-Jie Chen, Hai-Xia Liu, Zhu-Jun Yao
State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
Qi-Cai Xiao, Sheng Jiang
Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GBZ. Performed the experiments: YQL XC LXG CM YJC HXL QCX. Analyzed the data: SJ ZJY GBZ. Contributed reagents/materials/analysis tools: SJ ZJY. Wrote the paper: ZJY GBZ.