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Research Article

High Bias Gas Flows Increase Lung Injury in the Ventilated Preterm Lamb

  • Katinka P. Bach mail,

    kittyb@adhb.govt.nz

    Affiliations: Liggins Institute, University of Auckland, Auckland, New Zealand, Newborn Services, Auckland City Hospital, Auckland, New Zealand

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  • Carl A. Kuschel,

    Affiliation: Royal Women’s Hospital, Parkville, Victoria, Australia

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  • Stuart B. Hooper,

    Affiliation: The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia

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  • Jean Bertram,

    Affiliation: Newborn Services, Auckland City Hospital, Auckland, New Zealand

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  • Sue McKnight,

    Affiliation: Newborn Services, Auckland City Hospital, Auckland, New Zealand

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  • Shirley E. Peachey,

    Affiliation: Newborn Services, Auckland City Hospital, Auckland, New Zealand

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  • Valerie A. Zahra,

    Affiliation: The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia

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  • Sharon J. Flecknoe,

    Affiliation: The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia

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  • Mark H. Oliver,

    Affiliations: Liggins Institute, University of Auckland, Auckland, New Zealand, National Research Centre for Growth and Development, Auckland, New Zealand

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  • Megan J. Wallace,

    Affiliation: The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia

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  • Frank H. Bloomfield

    Affiliations: Liggins Institute, University of Auckland, Auckland, New Zealand, Newborn Services, Auckland City Hospital, Auckland, New Zealand, National Research Centre for Growth and Development, Auckland, New Zealand, Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047044

About the Authors

Katinka P. Bach, Mark H. Oliver, Frank H. Bloomfield
Liggins Institute, University of Auckland, Auckland, New Zealand
Carl A. Kuschel
Royal Women’s Hospital, Parkville, Victoria, Australia
Stuart B. Hooper, Valerie A. Zahra, Sharon J. Flecknoe, Megan J. Wallace
The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia
Katinka P. Bach, Jean Bertram, Sue McKnight, Shirley E. Peachey, Frank H. Bloomfield
Newborn Services, Auckland City Hospital, Auckland, New Zealand
Mark H. Oliver, Frank H. Bloomfield
National Research Centre for Growth and Development, Auckland, New Zealand
Frank H. Bloomfield
Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Corresponding Author

Email: kittyb@adhb.govt.nz

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FHB KPB CAK SBH. Performed the experiments: FHB KPB CAH JB SM SEP VAZ SJF MHO MJW. Analyzed the data: KPB FHB SBH MJW. Contributed reagents/materials/analysis tools: FHB SHB SJF MJW. Wrote the paper: KPB SBH FHB.