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Research Article

Cajaninstilbene Acid Relaxes Rat Renal Arteries: Roles of Ca2+ Antagonism and Protein Kinase C-Dependent Mechanism

  • Dong-Mei Zhang equal contributor,

    equal contributor Contributed equally to this work with: Dong-Mei Zhang, Yong Li, Wai San Cheang

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Yong Li equal contributor,

    equal contributor Contributed equally to this work with: Dong-Mei Zhang, Yong Li, Wai San Cheang

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Wai San Cheang equal contributor,

    equal contributor Contributed equally to this work with: Dong-Mei Zhang, Yong Li, Wai San Cheang

    Affiliation: Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China

    X
  • Chi Wai Lau,

    Affiliation: Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China

    X
  • Shun-Ming Lin,

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Qian-Lan Zhang,

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Nan Yao,

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Ying Wang,

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Xin Wu,

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Yu Huang mail,

    chywc@yahoo.com.cn (WCY); yu-huang@cuhk.edu.hk (YH)

    Affiliation: Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China

    X
  • Wen-Cai Ye mail

    chywc@yahoo.com.cn (WCY); yu-huang@cuhk.edu.hk (YH)

    Affiliations: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China

    X
  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047030

About the Authors

Dong-Mei Zhang, Yong Li, Shun-Ming Lin, Qian-Lan Zhang, Nan Yao, Ying Wang, Xin Wu, Wen-Cai Ye
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China
Dong-Mei Zhang, Yong Li, Shun-Ming Lin, Qian-Lan Zhang, Nan Yao, Ying Wang, Xin Wu, Wen-Cai Ye
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, China
Wai San Cheang, Chi Wai Lau, Yu Huang
Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMZ YL WSC YH WCY. Performed the experiments: DMZ YL WSC CWL SML QLZ NY. Analyzed the data: DMZ YL WSC CWL SML YH. Contributed reagents/materials/analysis tools: YW XW. Wrote the paper: DMZ YL WSC YH.