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Research Article

Obesity Induced by Neonatal Overfeeding Worsens Airway Hyperresponsiveness and Inflammation

  • Zehui Ye,

    Affiliations: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, Department of Respiratory Medicine, Chongqing Medical University, Chongqing, China, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Medical University, Chongqing, China, Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children’s Hospital, Chongqing Medical University, Chongqing, China

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  • Ying Huang mail,

    xiaoxq@cqmu.edu.cn (XX); huangying62@126.com (YH)

    Affiliations: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, Department of Respiratory Medicine, Chongqing Medical University, Chongqing, China, Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China

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  • Dan Liu,

    Affiliations: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Medical University, Chongqing, China, Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children’s Hospital, Chongqing Medical University, Chongqing, China

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  • Xiaoyi Chen,

    Affiliations: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Medical University, Chongqing, China, Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children’s Hospital, Chongqing Medical University, Chongqing, China

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  • Dongjuan Wang,

    Affiliations: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, Department of Respiratory Medicine, Chongqing Medical University, Chongqing, China, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Medical University, Chongqing, China, Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children’s Hospital, Chongqing Medical University, Chongqing, China

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  • Daochao Huang,

    Affiliation: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China

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  • Li Zhao,

    Affiliation: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China

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  • Xiaoqiu Xiao mail

    xiaoxq@cqmu.edu.cn (XX); huangying62@126.com (YH)

    Affiliations: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Medical University, Chongqing, China, Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children’s Hospital, Chongqing Medical University, Chongqing, China

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047013

About the Authors

Zehui Ye, Ying Huang, Dan Liu, Xiaoyi Chen, Dongjuan Wang, Daochao Huang, Li Zhao, Xiaoqiu Xiao
Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China
Zehui Ye, Ying Huang, Dongjuan Wang
Department of Respiratory Medicine, Chongqing Medical University, Chongqing, China
Zehui Ye, Dan Liu, Xiaoyi Chen, Dongjuan Wang, Xiaoqiu Xiao
Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Medical University, Chongqing, China
Zehui Ye, Ying Huang, Dan Liu, Xiaoyi Chen, Dongjuan Wang, Xiaoqiu Xiao
Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China
Zehui Ye, Dan Liu, Xiaoyi Chen, Dongjuan Wang, Xiaoqiu Xiao
Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children’s Hospital, Chongqing Medical University, Chongqing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XX YH. Performed the experiments: ZY DL XC DW DH LZ. Analyzed the data: ZY XX. Contributed reagents/materials/analysis tools: XX YH. Wrote the paper: ZY XX YH.