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Research Article

CD154 and IL-2 Signaling of CD4+ T Cells Play a Critical Role in Multiple Phases of CD8+ CTL Responses Following Adenovirus Vaccination

  • Channakeshava Sokke Umeshappa,

    Affiliations: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Departments of Oncology and Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Current address: Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Roopa Hebbandi Nanjundappa,

    Affiliation: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Current address: Department of Microbiology, Immunology & Infectious Diseases, Health Research Innovation Centre, University of Calgary, Calgary, Alberta, Canada

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  • Yufeng Xie,

    Affiliation: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

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  • Andrew Freywald,

    Affiliation: Departments of Oncology and Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

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  • Yulin Deng,

    Affiliation: Beijing Institute of Technology, Beijing, China

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  • Hong Ma,

    Affiliation: Beijing Institute of Technology, Beijing, China

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  • Jim Xiang mail

    jim.xiang@saskcancer.ca

    Affiliations: Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Departments of Oncology and Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, Beijing Institute of Technology, Beijing, China

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0047004

About the Authors

Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, Yufeng Xie, Jim Xiang
Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Channakeshava Sokke Umeshappa, Andrew Freywald, Jim Xiang
Departments of Oncology and Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Yulin Deng, Hong Ma, Jim Xiang
Beijing Institute of Technology, Beijing, China

Corresponding Author

Email: jim.xiang@saskcancer.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JX. Performed the experiments: CSU RHN YX. Analyzed the data: JX CSU. Wrote the paper: CSU JX. Editing: AF YD HM.