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Research Article

Regulation of the CCL2 Gene in Pancreatic β-Cells by IL-1β and Glucocorticoids: Role of MKP-1

  • Susan J. Burke,

    Affiliation: Department of Nutrition, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Matthew R. Goff,

    Affiliation: Department of Nutrition, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Barrett L. Updegraff,

    Affiliation: Department of Nutrition, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Danhong Lu,

    Affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Patricia L. Brown,

    Affiliation: Advanced Microscopy and Imaging Center, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Steven C. Minkin Jr.,

    Affiliation: Advanced Microscopy and Imaging Center, University of Tennessee, Knoxville, Tennessee, United States of America

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  • John P. Biggerstaff,

    Affiliation: Advanced Microscopy and Imaging Center, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Ling Zhao,

    Affiliations: Department of Nutrition, University of Tennessee, Knoxville, Tennessee, United States of America, University of Tennessee Obesity Research Center, Knoxville, Tennessee, United States of America

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  • Michael D. Karlstad,

    Affiliations: Department of Nutrition, University of Tennessee, Knoxville, Tennessee, United States of America, Department of Surgery, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee, United States of America, University of Tennessee Obesity Research Center, Knoxville, Tennessee, United States of America

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  • J. Jason Collier mail

    Jason.Collier@utk.edu

    Affiliations: Department of Nutrition, University of Tennessee, Knoxville, Tennessee, United States of America, University of Tennessee Obesity Research Center, Knoxville, Tennessee, United States of America

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0046986

About the Authors

Susan J. Burke, Matthew R. Goff, Barrett L. Updegraff, Ling Zhao, Michael D. Karlstad, J. Jason Collier
Department of Nutrition, University of Tennessee, Knoxville, Tennessee, United States of America
Danhong Lu
Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America
Patricia L. Brown, Steven C. Minkin Jr., John P. Biggerstaff
Advanced Microscopy and Imaging Center, University of Tennessee, Knoxville, Tennessee, United States of America
Michael D. Karlstad
Department of Surgery, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee, United States of America
Ling Zhao, Michael D. Karlstad, J. Jason Collier
University of Tennessee Obesity Research Center, Knoxville, Tennessee, United States of America

Corresponding Author

Email: Jason.Collier@utk.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJB JJC. Performed the experiments: SJB MRG BLU DL PLB SCM LZ JJC. Analyzed the data: SJB MRG SCM DL MDK JJC. Contributed reagents/materials/analysis tools: SJB JPB DL LZ MDK JJC. Wrote the paper: SJB JJC.