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Research Article

Mannosylated Mucin-Type Immunoglobulin Fusion Proteins Enhance Antigen-Specific Antibody and T Lymphocyte Responses

  • Gustaf Ahlén equal contributor mail,

    equal contributor Contributed equally to this work with: Gustaf Ahlén, Lena Strindelius

    gustaf.ahlen@ki.se

    Affiliation: Recopharma AB, Stockholm, Sweden

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  • Lena Strindelius equal contributor,

    equal contributor Contributed equally to this work with: Gustaf Ahlén, Lena Strindelius

    Affiliation: Recopharma AB, Stockholm, Sweden

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  • Tomas Johansson,

    Affiliation: Recopharma AB, Stockholm, Sweden

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  • Anki Nilsson,

    Affiliation: Recopharma AB, Stockholm, Sweden

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  • Nathalie Chatzissavidou,

    Affiliation: Recopharma AB, Stockholm, Sweden

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  • Magnus Sjöblom,

    Affiliation: Biochemical and Chemical Process Engineering, Luleå University of Technology, Luleå, Sweden

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  • Ulrika Rova,

    Affiliation: Biochemical and Chemical Process Engineering, Luleå University of Technology, Luleå, Sweden

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  • Jan Holgersson

    Affiliation: Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, Gothenburg, Sweden

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  • Published: October 12, 2012
  • DOI: 10.1371/journal.pone.0046959

About the Authors

Gustaf Ahlén, Lena Strindelius, Tomas Johansson, Anki Nilsson, Nathalie Chatzissavidou
Recopharma AB, Stockholm, Sweden
Magnus Sjöblom, Ulrika Rova
Biochemical and Chemical Process Engineering, Luleå University of Technology, Luleå, Sweden
Jan Holgersson
Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, Gothenburg, Sweden

Corresponding Author

Email: gustaf.ahlen@ki.se

Competing Interests

JH is acting CEO, board member and shareholder of Recopharma AB. At the time of the study, GA, LS, TJ, AN, and NC were employees of Recopharma. MS has been partly funded by Recopharma through a research grant to LTU. The technology described in the manuscript has been patent-sought by Recopharma, “Production of Human Glycosylated Proteins in Yeast and Methods of Use Thereof” (United States application number 11/626156. Filing date 23-Jan-2007.) (WO application number PCT/IB2007/004164. Filing date 23-Jan-2007.) This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GA LS JH UR. Performed the experiments: GA LS TJ NC MS. Analyzed the data: GA LS TJ JH. Contributed reagents/materials/analysis tools: TJ AN NC MS. Wrote the paper: GA LS TJ MS JH.