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Research Article

Antenatal Screening for Down Syndrome Using Serum Placental Growth Factor with the Combined, Quadruple, Serum Integrated and Integrated Tests

  • Nicholas J. Wald mail,

    n.j.wald@qmul.ac.uk

    Affiliation: Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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  • Jonathan P. Bestwick,

    Affiliation: Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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  • Lynne M. George,

    Affiliation: Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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  • Wayne J. Huttly

    Affiliation: Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046955

About the Authors

Nicholas J. Wald, Jonathan P. Bestwick, Lynne M. George, Wayne J. Huttly
Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Corresponding Author

Email: n.j.wald@qmul.ac.uk

Competing Interests

The authors have the following interests: PerkinElmer provided the PlGF assay kits free of charge. N. Wald has a patent for the Integrated test as follows: Application No.; Country; Filing Date; Patent No.; Issue/Grant Date 09/301,621; US; 29.04.99; 6,573,103; 03.06.03 36213/99; Australia; 29.04.99; 763171; 31.10.06 2330538; Canada; 29.04.99; 2330538; 11.09.07 99918188; Europe; 29.04.99; 1076824; 14.06.06 139302; Israel; 29.04.99; 139302; 26.10.05 With others, he held a patent in connection with the use of uE3 as a second trimester screening marker in prenatal screening for Down syndrome, although this has now expired. He is Director of Logical Medical Systems Ltd, which produces software for the interpretation of Down syndrome screening tests. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: NW. Performed the experiments: NW JB LG WH. Analyzed the data: NW JB. Wrote the paper: NW JB LG WH.