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Research Article

Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes

  • Jian Wu,

    Affiliations: Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, United States of America, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China

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  • Dorothy N. Kakoola,

    Affiliations: Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, United States of America

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  • Nataliya I. Lenchik,

    Affiliations: Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, United States of America

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  • Dominic M. Desiderio,

    Affiliations: Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Department of Neurology, Department of Molecular Science, and the Charles B. Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Dana R. Marshall,

    Affiliations: Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, United States of America, Department of Pathology, Anatomy and Cell Biology, School of Medicine, Meharry Medical College, Nashville, Tennessee, United States of America

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  • Ivan C. Gerling mail

    igerling@uthsc.edu

    Affiliations: Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, United States of America

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0046941

About the Authors

Jian Wu, Dorothy N. Kakoola, Nataliya I. Lenchik, Dominic M. Desiderio, Ivan C. Gerling
Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
Jian Wu, Dorothy N. Kakoola, Nataliya I. Lenchik, Dana R. Marshall, Ivan C. Gerling
Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, United States of America
Dominic M. Desiderio
Department of Neurology, Department of Molecular Science, and the Charles B. Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
Jian Wu
Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
Dana R. Marshall
Department of Pathology, Anatomy and Cell Biology, School of Medicine, Meharry Medical College, Nashville, Tennessee, United States of America

Corresponding Author

Email: igerling@uthsc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ICG. Performed the experiments: JW DNK NIL. Analyzed the data: JW DNK. Contributed reagents/materials/analysis tools: DMD DRM. Wrote the paper: JW DNK ICG. Interpreted the data: JW DNK ICG. Provided intellectual input: DMD DRM. Supervised the research: ICG.