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Research Article

Pax6 Directly Down-Regulates Pcsk1n Expression Thereby Regulating PC1/3 Dependent Proinsulin Processing

  • Ting Liu,

    Affiliation: Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

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  • Yanxia Zhao,

    Affiliation: Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

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  • Na Tang,

    Affiliation: Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

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  • Ruopeng Feng,

    Affiliation: Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

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  • Xiaolong Yang,

    Affiliation: Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

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  • Nicole Lu,

    Affiliation: SARI Center for Stem Cell and Nanomedicine, Shanghai Advanced Research Institute, CAS, Shanghai, China

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  • Jinhua Wen mail,

    jhwen@bjmu.edu.cn

    Affiliation: Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

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  • Lingsong Li

    Affiliations: Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, SARI Center for Stem Cell and Nanomedicine, Shanghai Advanced Research Institute, CAS, Shanghai, China

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0046934

About the Authors

Ting Liu, Yanxia Zhao, Na Tang, Ruopeng Feng, Xiaolong Yang, Jinhua Wen, Lingsong Li
Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Nicole Lu, Lingsong Li
SARI Center for Stem Cell and Nanomedicine, Shanghai Advanced Research Institute, CAS, Shanghai, China

Corresponding Author

Email: jhwen@bjmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHW TL. Performed the experiments: TL YXZ NT. Analyzed the data: JHW TL. Contributed reagents/materials/analysis tools: YXZ NT RPF XLY. Wrote the paper: JHW LSL. Edited writing: NL.