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Research Article

IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

  • Silvia Lorenzi equal contributor,

    equal contributor Contributed equally to this work with: Silvia Lorenzi, Matteo Forloni

    Affiliation: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Matteo Forloni equal contributor,

    equal contributor Contributed equally to this work with: Silvia Lorenzi, Matteo Forloni

    Affiliation: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Loredana Cifaldi,

    Affiliation: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Chiara Antonucci,

    Affiliation: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Arianna Citti,

    Affiliation: Pathology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Renata Boldrini,

    Affiliation: Pathology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Marco Pezzullo,

    Affiliation: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Aurora Castellano,

    Affiliation: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Vincenzo Russo,

    Affiliation: Cancer Gene Therapy Unit, Scientific Institute San Raffaele, Milan, Italy

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  • Pierre van der Bruggen,

    Affiliation: Laboratory of Immunology CRS, Regina Elena National Cancer Institute, Rome, Italy

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  • Patrizio Giacomini,

    Affiliation: Ludwig Institute for Cancer Research and Université Catholique de Louvain, de Duve Institute, Brussels, Belgium

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  • Franco Locatelli,

    Affiliations: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy, University of Pavia, Pavia, Italy

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  • Doriana Fruci mail

    fruci@opbg.net

    Affiliation: Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046928

About the Authors

Silvia Lorenzi, Matteo Forloni, Loredana Cifaldi, Chiara Antonucci, Marco Pezzullo, Aurora Castellano, Franco Locatelli, Doriana Fruci
Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Arianna Citti, Renata Boldrini
Pathology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Vincenzo Russo
Cancer Gene Therapy Unit, Scientific Institute San Raffaele, Milan, Italy
Pierre van der Bruggen
Laboratory of Immunology CRS, Regina Elena National Cancer Institute, Rome, Italy
Patrizio Giacomini
Ludwig Institute for Cancer Research and Université Catholique de Louvain, de Duve Institute, Brussels, Belgium
Franco Locatelli
University of Pavia, Pavia, Italy

Corresponding Author

Email: fruci@opbg.net

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL MF DF. Performed the experiments: SL MF LC CA A. Citti MP RB. Analyzed the data: SL MF LC DF. Contributed reagents/materials/analysis tools: A. Castellano VR PB PG FL. Wrote the paper: DF.