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Research Article

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

  • Luís Martins,

    Affiliations: Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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  • Diana Fernández-Mallo,

    Affiliations: Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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  • Marta G. Novelle,

    Affiliations: Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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  • María J. Vázquez,

    Affiliations: Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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  • Manuel Tena-Sempere,

    Affiliations: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain, Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba, Spain, Instituto Maimónides de Investigaciones Biomédicas (IMIBIC), Córdoba, Spain

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  • Rubén Nogueiras,

    Affiliations: Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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  • Miguel López mail,

    m.lopez@usc.es (ML); carlos.dieguez@usc.es (CD)

    Affiliations: Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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  • Carlos Diéguez mail

    m.lopez@usc.es (ML); carlos.dieguez@usc.es (CD)

    Affiliations: Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0046923

About the Authors

Luís Martins, Diana Fernández-Mallo, Marta G. Novelle, María J. Vázquez, Rubén Nogueiras, Miguel López, Carlos Diéguez
Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain
Luís Martins, Diana Fernández-Mallo, Marta G. Novelle, María J. Vázquez, Manuel Tena-Sempere, Rubén Nogueiras, Miguel López, Carlos Diéguez
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Manuel Tena-Sempere
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba, Spain
Manuel Tena-Sempere
Instituto Maimónides de Investigaciones Biomédicas (IMIBIC), Córdoba, Spain

Corresponding Authors

Competing Interests

Co-authors Manuel Tena-Sempere and Miguel López are PLOS ONE Editorial Board members. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MTS RN ML CD. Performed the experiments: LM DFM MGN MJV. Analyzed the data: LM DFM ML. Wrote the paper: ML.