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Research Article

Prevention of Bone Growth Defects, Increased Bone Resorption and Marrow Adiposity with Folinic Acid in Rats Receiving Long-Term Methotrexate

  • Chia-Ming Fan,

    Affiliations: Sansom Institute for Health Research, and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia, Discipline of Paediatrics, University of Adelaide, Adelaide, SA, Australia

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  • Bruce K. Foster,

    Affiliations: Discipline of Paediatrics, University of Adelaide, Adelaide, SA, Australia, Department of Orthopaedic Surgery, Women’s and Children’s Hospital, North Adelaide, SA, Australia

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  • Susanta K. Hui,

    Affiliation: Masonic Cancer Center and Department of Therapeutic Radiology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Cory J. Xian mail

    cory.xian@unisa.edu.au

    Affiliations: Sansom Institute for Health Research, and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia, Discipline of Paediatrics, University of Adelaide, Adelaide, SA, Australia, Department of Orthopaedic Surgery, Women’s and Children’s Hospital, North Adelaide, SA, Australia

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046915

About the Authors

Chia-Ming Fan, Cory J. Xian
Sansom Institute for Health Research, and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia
Chia-Ming Fan, Bruce K. Foster, Cory J. Xian
Discipline of Paediatrics, University of Adelaide, Adelaide, SA, Australia
Bruce K. Foster, Cory J. Xian
Department of Orthopaedic Surgery, Women’s and Children’s Hospital, North Adelaide, SA, Australia
Susanta K. Hui
Masonic Cancer Center and Department of Therapeutic Radiology, University of Minnesota, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: cory.xian@unisa.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CMF CJX. Performed the experiments: CMF CJX. Analyzed the data: CMF BKF CJX. Contributed reagents/materials/analysis tools: CMF BKF CJX. Wrote the paper: CMF SKH CJX.