Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells

Katharina Bell; Sebastian Funke; Norbert Pfeiffer; Franz H. Grus

doi:10.1371/journal.pone.0046910

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Open Access

Peer-reviewed

Research Article

Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells

Katharina Bell,

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany
⨯
Sebastian Funke,

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany
⨯
Norbert Pfeiffer,

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany
⨯
Franz H. Grus

* E-mail: grus@eye-research.org

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany
⨯

Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells

Katharina Bell,
Sebastian Funke,
Norbert Pfeiffer,
Franz H. Grus

Published: October 11, 2012
https://doi.org/10.1371/journal.pone.0046910

About the Authors

Katharina Bell

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany

Sebastian Funke

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany

Norbert Pfeiffer

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany

Franz H. Grus

* E-mail: grus@eye-research.org

Affiliation Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University, Mainz, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KB FHG SF. Performed the experiments: KB. Analyzed the data: KB FHG. Contributed reagents/materials/analysis tools: FHG NP. Wrote the paper: KB.

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Serum proteins
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Glaucoma
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Apoptosis
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Retinal ganglion cells
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Protein expression
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Cell viability testing
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Autoantibodies
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Body weight
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