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Research Article

Altered Plasma Apolipoprotein Modifications in Patients with Pancreatic Cancer: Protein Characterization and Multi-Institutional Validation

  • Kazufumi Honda,

    Affiliation: Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan

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  • Takuji Okusaka,

    Affiliation: Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan

    X
  • Klaus Felix,

    Affiliation: Department of Surgery, University of Heidelberg, Heidelberg, Germany

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  • Shoji Nakamori,

    Affiliation: Department of Surgery, Osaka National Hospital, National Hospital Organization, Osaka, Japan

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  • Naohiro Sata,

    Affiliation: Department of Surgery, Jichi Medical University, Shimotsuke, Japan

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  • Hideo Nagai,

    Affiliation: Department of Surgery, Jichi Medical University, Shimotsuke, Japan

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  • Tatsuya Ioka,

    Affiliation: Department of Hepatobiliary and Pancreatic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

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  • Akihiko Tsuchida,

    Affiliation: Third Department of Surgery, Tokyo Medical University, Tokyo, Japan

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  • Takeshi Shimahara,

    Affiliation: Department of Oral Surgery, Osaka Medical College, Osaka, Japan

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  • Masashi Shimahara,

    Affiliation: Department of Oral Surgery, Osaka Medical College, Osaka, Japan

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  • Yohichi Yasunami,

    Affiliation: Department of Regenerative Medicine and Transplantation, Fukuoka University Faculty of Medicine, Fukuoka, Japan

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  • Hideya Kuwabara,

    Affiliation: BioBusiness Group, Mitsui Knowledge Industry, Tokyo, Japan

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  • Tomohiro Sakuma,

    Affiliation: BioBusiness Group, Mitsui Knowledge Industry, Tokyo, Japan

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  • Yoshihiko Otsuka,

    Affiliation: Pancreatic Cancer Diagnosis Project, Molecuence Corporation, Yokohama, Japan

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  • Norihito Ota,

    Affiliation: Pancreatic Cancer Diagnosis Project, Molecuence Corporation, Yokohama, Japan

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  • Miki Shitashige,

    Affiliation: Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan

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  • Tomoo Kosuge,

    Affiliation: Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan

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  • Markus W. Büchler,

    Affiliation: Department of Surgery, University of Heidelberg, Heidelberg, Germany

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  • Tesshi Yamada mail

    tyamada@ncc.go.jp

    Affiliation: Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan

    X
  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046908

About the Authors

Kazufumi Honda, Miki Shitashige, Tesshi Yamada
Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
Takuji Okusaka
Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
Klaus Felix, Markus W. Büchler
Department of Surgery, University of Heidelberg, Heidelberg, Germany
Shoji Nakamori
Department of Surgery, Osaka National Hospital, National Hospital Organization, Osaka, Japan
Naohiro Sata, Hideo Nagai
Department of Surgery, Jichi Medical University, Shimotsuke, Japan
Tatsuya Ioka
Department of Hepatobiliary and Pancreatic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Akihiko Tsuchida
Third Department of Surgery, Tokyo Medical University, Tokyo, Japan
Takeshi Shimahara, Masashi Shimahara
Department of Oral Surgery, Osaka Medical College, Osaka, Japan
Yohichi Yasunami
Department of Regenerative Medicine and Transplantation, Fukuoka University Faculty of Medicine, Fukuoka, Japan
Hideya Kuwabara, Tomohiro Sakuma
BioBusiness Group, Mitsui Knowledge Industry, Tokyo, Japan
Yoshihiko Otsuka, Norihito Ota
Pancreatic Cancer Diagnosis Project, Molecuence Corporation, Yokohama, Japan
Tomoo Kosuge
Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan

Corresponding Author

Email: tyamada@ncc.go.jp

Competing Interests

HK and TS are the employees of Mitsui Knowledge Industry, and YO and NO used to belong to Molecuence Corporation. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The authors have declared that no other competing interests exist.

Author Contributions

Conceived and designed the experiments: KH TY. Performed the experiments: KH YO NO. Analyzed the data: KH HK T. Sakuma M. Shitashige. Contributed reagents/materials/analysis tools: TO KF SN NS HN TI AT T. Shimahara M. Shimahara YY TK MWB. Wrote the paper: KH TY.