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Research Article

EGFR Inhibition Abrogates Leiomyosarcoma Cell Chemoresistance through Inactivation of Survival Pathways and Impairment of CSC Potential

  • Giovanni Sette,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Valentina Salvati,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Lorenzo Memeo,

    Affiliation: Mediterranean Institute of Oncology, Catania, Italy

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  • Katia Fecchi,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Cristina Colarossi,

    Affiliation: Mediterranean Institute of Oncology, Catania, Italy

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  • Paola Di Matteo,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Michele Signore,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Mauro Biffoni,

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Vito D’Andrea,

    Affiliation: Department of Surgical Sciences, La Sapienza University of Rome, Italy

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  • Enrico De Antoni,

    Affiliation: Department of Surgical Sciences, La Sapienza University of Rome, Italy

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  • Vincenzo Canzonieri,

    Affiliation: Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy

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  • Ruggero De Maria,

    Affiliation: Regina Elena National Cancer Institute, Rome, Italy

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  • Adriana Eramo mail

    adriana.eramo@iss.it

    Affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046891

About the Authors

Giovanni Sette, Valentina Salvati, Katia Fecchi, Paola Di Matteo, Michele Signore, Mauro Biffoni, Adriana Eramo
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
Lorenzo Memeo, Cristina Colarossi
Mediterranean Institute of Oncology, Catania, Italy
Vito D’Andrea, Enrico De Antoni
Department of Surgical Sciences, La Sapienza University of Rome, Italy
Vincenzo Canzonieri
Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Ruggero De Maria
Regina Elena National Cancer Institute, Rome, Italy

Corresponding Author

Email: adriana.eramo@iss.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AE GS RDM. Performed the experiments: GS KF VS LM CC MB MS. Analyzed the data: AE GS RDM. Contributed reagents/materials/analysis tools: VDA EDA VC PDM. Wrote the paper: AE GS RDM.