Advertisement
Research Article

Bioengineered Nisin A Derivatives with Enhanced Activity against Both Gram Positive and Gram Negative Pathogens

  • Des Field,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

    X
  • Maire Begley,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

    X
  • Paula M. O’Connor,

    Affiliation: Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland

    X
  • Karen M. Daly,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

    X
  • Floor Hugenholtz,

    Affiliation: Department of Microbiology, University College Cork, Cork, Ireland

    X
  • Paul D. Cotter mail,

    paul.cotter@teagasc.ie (PDC); c.hill@ucc.ie (CH)

    Affiliations: Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

    X
  • Colin Hill mail,

    paul.cotter@teagasc.ie (PDC); c.hill@ucc.ie (CH)

    Affiliations: Department of Microbiology, University College Cork, Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

    X
  • R. Paul Ross

    Affiliations: Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

    X
  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046884

About the Authors

Des Field, Maire Begley, Karen M. Daly, Floor Hugenholtz, Colin Hill
Department of Microbiology, University College Cork, Cork, Ireland
Paula M. O’Connor, Paul D. Cotter, R. Paul Ross
Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland
Paul D. Cotter, Colin Hill, R. Paul Ross
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CH PDC MB DF. Performed the experiments: DF MB KD FH PO. Analyzed the data: DF MB PO. Contributed reagents/materials/analysis tools: CH RPR. Wrote the paper: DF.