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Research Article

AZD1480 Blocks Growth and Tumorigenesis of RET- Activated Thyroid Cancer Cell Lines

  • Joana P. Couto,

    Affiliations: Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal

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  • Ana Almeida,

    Affiliations: Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal, Institute of Biomedical Sciences Abel Salazar of the University of Porto, Porto, Portugal

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  • Laura Daly,

    Affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Manuel Sobrinho-Simões,

    Affiliations: Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal, Department of Pathology, Hospital São João, Porto, Portugal

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  • Jacqueline F. Bromberg mail,

    psoares@ipatimup.pt (PS); bromberj@mskcc.org (JFB)

    Affiliations: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

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  • Paula Soares mail

    psoares@ipatimup.pt (PS); bromberj@mskcc.org (JFB)

    Affiliations: Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal, Faculty of Medicine of the University of Porto, Porto, Portugal

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  • Published: October 02, 2012
  • DOI: 10.1371/journal.pone.0046869

About the Authors

Joana P. Couto, Ana Almeida, Manuel Sobrinho-Simões, Paula Soares
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Cancer Biology, Porto, Portugal
Joana P. Couto, Ana Almeida, Manuel Sobrinho-Simões, Paula Soares
Faculty of Medicine of the University of Porto, Porto, Portugal
Ana Almeida
Institute of Biomedical Sciences Abel Salazar of the University of Porto, Porto, Portugal
Laura Daly, Jacqueline F. Bromberg
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Manuel Sobrinho-Simões
Department of Pathology, Hospital São João, Porto, Portugal
Jacqueline F. Bromberg
Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

Corresponding Authors

Competing Interests

Jacqueline Bromberg has received research funding from AstraZeneca. She has had an advisory role at AstraZeneca and Mediummune and received honoria for lectures. There are no patents or products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JPC JFB PS. Performed the experiments: AA LD. Analyzed the data: JPC MSS JFB PS. Contributed reagents/materials/analysis tools: JFB PS. Wrote the paper: JPC JFB PS.