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Research Article

Oligomerization of Clostridium perfringens Epsilon Toxin Is Dependent upon Caveolins 1 and 2

  • Christine M. Fennessey,

    Affiliation: Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Jinsong Sheng,

    Affiliation: Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Donald H. Rubin,

    Affiliations: Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Research Medicine, VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

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  • Mark S. McClain mail

    mark.mcclain@vanderbilt.edu

    Affiliation: Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Published: October 02, 2012
  • DOI: 10.1371/journal.pone.0046866

About the Authors

Christine M. Fennessey, Jinsong Sheng, Donald H. Rubin, Mark S. McClain
Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Donald H. Rubin
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Donald H. Rubin
Research Medicine, VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

Corresponding Author

Email: mark.mcclain@vanderbilt.edu

Competing Interests

DHR is a scientific founder of Zirus, Inc., and performed genomic analysis of the insertion sites of the gene-trap vector. An external auditor at Vanderbilt University reviews DHR’s laboratory and reports are available from David Raiford, Associate Dean for Faculty Affairs, Vanderbilt Medical School. Thus, none of the authors declare competing interests with respect to gene identification or validation. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CMF DHR MSM. Performed the experiments: CMF JS DHR MSM. Analyzed the data: CMF DHR MSM. Contributed reagents/materials/analysis tools: DHR MSM. Wrote the paper: CMF DHR MSM.