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Research Article

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

  • Lin Qi equal contributor,

    equal contributor Contributed equally to this work with: Lin Qi, Xing-Ding Zhang

    Affiliation: Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China

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  • Xing-Ding Zhang equal contributor,

    equal contributor Contributed equally to this work with: Lin Qi, Xing-Ding Zhang

    Affiliation: Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China

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  • Jun-Chao Wu,

    Affiliation: Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China

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  • Fang Lin,

    Affiliation: Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China

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  • Jin Wang,

    Affiliation: Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China

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  • Marian DiFiglia,

    Affiliation: Laboratory of Cellular Neurobiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Zheng-Hong Qin mail

    qinzhenhong@suda.edu.cn

    Affiliation: Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0046834

About the Authors

Lin Qi, Xing-Ding Zhang, Jun-Chao Wu, Fang Lin, Jin Wang, Zheng-Hong Qin
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
Marian DiFiglia
Laboratory of Cellular Neurobiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America

Corresponding Author

Email: qinzhenhong@suda.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LQ XDZ ZHQ. Analyzed the data: LQ XDZ JCW FL JW. Wrote the paper: LQ XDZ ZHQ. Revising article critically for important intellectual content: LQ XDZ MD ZHQ. Approval for the final version to be published: LQ XDZ MD ZHQ..