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Research Article

Calcium Chelation by Alginate Activates the Type III Secretion System in Mucoid Pseudomonas aeruginosa Biofilms

  • Shawn R. Horsman,

    Affiliation: Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Richard A. Moore,

    Affiliation: Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Shawn Lewenza mail

    slewenza@ucalgary.ca

    Affiliation: Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046826

About the Authors

Shawn R. Horsman, Richard A. Moore, Shawn Lewenza
Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

Corresponding Author

Email: slewenza@ucalgary.ca

Competing Interests

The authors have the following interests. This research was partly supported by the Westaim Corporation, and SL holds the Westaim-ASRA Chair in Biofilm Research. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SRH SL. Performed the experiments: SRH RAM SL. Analyzed the data: SRH RAM SL. Contributed reagents/materials/analysis tools: SRH SL. Wrote the paper: SRH SL.