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Research Article

TRIM38 Negatively Regulates TLR3-Mediated IFN-β Signaling by Targeting TRIF for Degradation

  • Qinghua Xue,

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

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  • Zhuo Zhou,

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

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  • Xiaobo Lei,

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

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  • Xinlei Liu,

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

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  • Bin He,

    Affiliation: Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, Illinois, United States of America

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  • Jianwei Wang mail,

    wangjw28@163.com

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

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  • Tao Hung

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046825

About the Authors

Qinghua Xue, Zhuo Zhou, Xiaobo Lei, Xinlei Liu, Jianwei Wang, Tao Hung
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China
Bin He
Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, Illinois, United States of America

Corresponding Author

Email: wangjw28@163.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QX ZZ JW TH. Performed the experiments: QX ZZ X. Lei X. Liu. Analyzed the data: QX ZZ X. Lei BH. Contributed reagents/materials/analysis tools: QX X. Liu. Wrote the paper: QX ZZ JW.