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Research Article

Human Langerhans Cells Control Th Cells via Programmed Death-Ligand 1 in Response to Bacterial Stimuli and Nickel-Induced Contact Allergy

  • Manuel Hitzler,

    Affiliation: German Federal Institute for Risk Assessment (BfR), Department of Product Safety, Berlin, Germany

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  • Otto Majdic,

    Affiliation: Institute for Immunology, Medical University, Vienna, Austria

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  • Guido Heine,

    Affiliation: Department of Dermatology and Allergy, Allergy-Center-Charité, CCM, Charité-University Medicine Berlin, Berlin, Germany

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  • Margitta Worm,

    Affiliation: Department of Dermatology and Allergy, Allergy-Center-Charité, CCM, Charité-University Medicine Berlin, Berlin, Germany

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  • Grit Ebert,

    Affiliation: Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Andreas Luch,

    Affiliation: German Federal Institute for Risk Assessment (BfR), Department of Product Safety, Berlin, Germany

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  • Matthias Peiser mail

    matthias.peiser@bfr.bund.de

    Affiliation: German Federal Institute for Risk Assessment (BfR), Department of Product Safety, Berlin, Germany

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0046776

About the Authors

Manuel Hitzler, Andreas Luch, Matthias Peiser
German Federal Institute for Risk Assessment (BfR), Department of Product Safety, Berlin, Germany
Otto Majdic
Institute for Immunology, Medical University, Vienna, Austria
Guido Heine, Margitta Worm
Department of Dermatology and Allergy, Allergy-Center-Charité, CCM, Charité-University Medicine Berlin, Berlin, Germany
Grit Ebert
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany

Corresponding Author

Email: matthias.peiser@bfr.bund.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MH MP. Performed the experiments: MH GE. Analyzed the data: MH MP. Contributed reagents/materials/analysis tools: OM GH MW. Wrote the paper: MP MH AL.