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Research Article

Divergent Resorbability and Effects on Osteoclast Formation of Commonly Used Bone Substitutes in a Human In Vitro-Assay

  • Johannes Keller equal contributor mail,

    equal contributor Contributed equally to this work with: Johannes Keller, Silja Brink

    j.keller@uke.de

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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  • Silja Brink equal contributor,

    equal contributor Contributed equally to this work with: Johannes Keller, Silja Brink

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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  • Björn Busse,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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  • Arndt F. Schilling,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Current address: Department of Plastic and Hand Surgery, Technische Universität München, Munich, Germany

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  • Thorsten Schinke,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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  • Michael Amling,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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  • Tobias Lange

    Affiliation: Department of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0046757

About the Authors

Johannes Keller, Silja Brink, Björn Busse, Arndt F. Schilling, Thorsten Schinke, Michael Amling
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Tobias Lange
Department of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Corresponding Author

Email: j.keller@uke.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AFS MA. Performed the experiments: SB TL BB. Analyzed the data: JK TL. Contributed reagents/materials/analysis tools: JK AFS TL. Wrote the paper: JK TL. Data interpretation: JK TS MA TL. Statistical analysis: JK TL. Critical manuscript revision: JK TS MA TL.