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Research Article

(−)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization

  • Yin Zhang,

    Affiliations: Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Nai-Di Yang,

    Affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Fan Zhou,

    Affiliation: Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Ting Shen,

    Affiliation: Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Ting Duan,

    Affiliation: Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Jing Zhou,

    Affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Yin Shi,

    Affiliation: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Xin-Qiang Zhu mail,

    zhuxq@zju.edu.cn (XQZ); han-ming_shen@nuhs.edu.sg (HMS)

    Affiliation: Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China

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  • Han-Ming Shen mail

    zhuxq@zju.edu.cn (XQZ); han-ming_shen@nuhs.edu.sg (HMS)

    Affiliations: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046749

About the Authors

Yin Zhang, Fan Zhou, Ting Shen, Ting Duan, Xin-Qiang Zhu
Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China
Yin Zhang, Nai-Di Yang, Jing Zhou, Yin Shi, Han-Ming Shen
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Han-Ming Shen
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
Han-Ming Shen
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YZ XQZ HMS. Performed the experiments: YZ NDY FZ TS TD JZ YS. Analyzed the data: YZ HMS. Wrote the paper: YZ HMS.