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Research Article

Negative Coupling as a Mechanism for Signal Propagation between C2 Domains of Synaptotagmin I

  • Michael E. Fealey,

    Affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota, United States of America

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  • Jacob W. Gauer,

    Affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota, United States of America

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  • Sarah C. Kempka,

    Affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota, United States of America

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  • Katie Miller,

    Affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota, United States of America

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  • Kamakshi Nayak,

    Affiliation: Department of Cell Physiology, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

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  • R. Bryan Sutton,

    Affiliation: Department of Cell Physiology, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

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  • Anne Hinderliter mail

    ahinderl@d.umn.edu

    Affiliation: Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota, United States of America

    X
  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046748

About the Authors

Michael E. Fealey, Jacob W. Gauer, Sarah C. Kempka, Katie Miller, Anne Hinderliter
Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota, United States of America
Kamakshi Nayak, R. Bryan Sutton
Department of Cell Physiology, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

Corresponding Author

Email: ahinderl@d.umn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AH JWG KM MEF SCK. Performed the experiments: JWG KM MEF SCK. Analyzed the data: JWG KM MEF SCK. Contributed reagents/materials/analysis tools: KN RBS. Wrote the paper: AH MEF RBS.