About the Authors

Robert P. Igo Jr

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Laura J. Kopplin

Affiliations Department of Ophthalmology, Casey Eye Institute, Portland, Oregon, United States of America, Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio, United States of America

Peronne Joseph

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Barbara Truitt

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Jeremy Fondran

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

David Bardenstein

Affiliation Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio, United States of America

Anthony J. Aldave

Affiliation The Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, United States of America

Christopher R. Croasdale

Affiliation David Duehr Dean Clinic, Madison, Wisconsin, United States of America

Marianne O. Price

Affiliation Price Vision Group, Indianapolis, Indiana, United States of America

Miriam Rosenwasser

Affiliation Central Pennsylvania Eye Institute, Hershey, Pennsylvania, United States of America

Jonathan H. Lass

Contributed equally to this work with: Jonathan H. Lass, Sudha K. Iyengar

Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio, United States of America

Sudha K. Iyengar

Contributed equally to this work with: Jonathan H. Lass, Sudha K. Iyengar

ski@case.edu

Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio, United States of America, Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America

for the FECD Genetics Multi-center Study Group

Membership of FECD Genetics Multi-center Study Group is detailed in the Acknowledgments.

Competing Interests

Dr. Marianne Price is affiliated with Price Vision Group, Indianapolis, Indiana. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JHL SKI. Analyzed the data: RPI LJK. Wrote the paper: RPI LJK PJ BT AJA CRC MOP MR JHL SKI. Collected the sample: DB AJA CRC MOP MR JHL SKI Designed and maintained the database for study data: JF. Collected genotype data: PJ BT.