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Research Article

Statins and Selective Inhibition of Rho Kinase Protect Small Conductance Calcium-Activated Potassium Channel Function (KCa2.3) in Cerebral Arteries

  • Alister J. McNeish equal contributor mail,

    equal contributor Contributed equally to this work with: Alister J. McNeish, Christopher J. Garland

    a.mcneish@reading.ac.uk

    Affiliation: Reading School of Pharmacy, University of Reading, Reading, Berkshire, United Kingdom

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  • Francesc Jimenez-Altayo,

    Affiliation: Department of Pharmacology, University of Oxford, Oxford, Oxfordshire, United Kingdom

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  • Graeme S. Cottrell,

    Affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath, Bath and North East Somerset, United Kingdom

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  • Christopher J. Garland equal contributor

    equal contributor Contributed equally to this work with: Alister J. McNeish, Christopher J. Garland

    Affiliation: Department of Pharmacology, University of Oxford, Oxford, Oxfordshire, United Kingdom

    X
  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046735

About the Authors

Alister J. McNeish
Reading School of Pharmacy, University of Reading, Reading, Berkshire, United Kingdom
Francesc Jimenez-Altayo, Christopher J. Garland
Department of Pharmacology, University of Oxford, Oxford, Oxfordshire, United Kingdom
Graeme S. Cottrell
Department of Pharmacy and Pharmacology, University of Bath, Bath, Bath and North East Somerset, United Kingdom

Corresponding Author

Email: a.mcneish@reading.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJM CJG GSC. Performed the experiments: AJM FJA GSC. Analyzed the data: AJM GSC. Contributed reagents/materials/analysis tools: AJM CJG GSC. Wrote the paper: AJM CJG.