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Research Article

Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice

  • Kennen B. MacKay,

    Affiliation: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Jonathan D. Lowenson,

    Affiliation: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Steven G. Clarke mail

    clarke@mbi.ucla.edu

    Affiliation: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046719

About the Authors

Kennen B. MacKay, Jonathan D. Lowenson, Steven G. Clarke
Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: clarke@mbi.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KBM JDL SGC. Performed the experiments: KBM JDL. Analyzed the data: KBM JDL SGC. Contributed reagents/materials/analysis tools: KBM JDL SGC. Wrote the paper: KBM JDL SGC.