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Research Article

Small Molecule-Based Promotion of PKCα-Mediated β-Catenin Degradation Suppresses the Proliferation of CRT-Positive Cancer Cells

  • Jungsug Gwak,

    Affiliations: Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul, Republic of Korea, PharmacoGenomics Research Center, Inje University, Busan, Republic of Korea

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  • Jee-Hyun Lee,

    Affiliation: College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea

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  • Young-Hwa Chung,

    Affiliation: WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea

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  • Gyu-Yong Song mail,

    ohsa@kookmin.ac.kr (SO); gysong@cnu.ac.kr (GYS)

    Affiliation: College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea

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  • Sangtaek Oh mail

    ohsa@kookmin.ac.kr (SO); gysong@cnu.ac.kr (GYS)

    Affiliations: Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul, Republic of Korea, PharmacoGenomics Research Center, Inje University, Busan, Republic of Korea

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046697

About the Authors

Jungsug Gwak, Sangtaek Oh
Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul, Republic of Korea
Jungsug Gwak, Sangtaek Oh
PharmacoGenomics Research Center, Inje University, Busan, Republic of Korea
Jee-Hyun Lee, Gyu-Yong Song
College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
Young-Hwa Chung
WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GYS SO. Performed the experiments: JG JHL. Analyzed the data: JG GYS SO. Contributed reagents/materials/analysis tools: YHC. Wrote the paper: JG GYS SO.