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Research Article

Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO2-Induced Epithelial Dysfunction

  • István Vadász,

    Affiliations: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America, Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany

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  • Laura A. Dada,

    Affiliation: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Arturo Briva,

    Affiliations: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America, Departamento de Fisiopatología, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay

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  • Iiro Taneli Helenius,

    Affiliations: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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  • Kfir Sharabi,

    Affiliation: Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel

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  • Lynn C. Welch,

    Affiliation: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Aileen M. Kelly,

    Affiliation: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Benno A. Grzesik,

    Affiliation: Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany

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  • G. R. Scott Budinger,

    Affiliation: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Jing Liu,

    Affiliation: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Werner Seeger,

    Affiliation: Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany

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  • Greg J. Beitel,

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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  • Yosef Gruenbaum,

    Affiliation: Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel

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  • Jacob I. Sznajder mail

    j-sznajder@northwestern.edu

    Affiliation: Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046696

About the Authors

István Vadász, Laura A. Dada, Arturo Briva, Iiro Taneli Helenius, Lynn C. Welch, Aileen M. Kelly, G. R. Scott Budinger, Jing Liu, Jacob I. Sznajder
Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America
István Vadász, Benno A. Grzesik, Werner Seeger
Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany
Arturo Briva
Departamento de Fisiopatología, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
Iiro Taneli Helenius, Greg J. Beitel
Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America
Kfir Sharabi, Yosef Gruenbaum
Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel

Corresponding Author

Email: j-sznajder@northwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IV LAD YG JIS. Performed the experiments: IV LAD AB ITH KS LCW AMK BG. Analyzed the data: IV LAD YG JIS. Contributed reagents/materials/analysis tools: GRSB JL WS GJB. Wrote the paper: IV LAD JIS GJB YG.