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Research Article

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

  • Sang-Hyug Park equal contributor,

    equal contributor Contributed equally to this work with: Sang-Hyug Park, Woo Young Sim

    Affiliations: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, United States of America, Department of Biomedical Engineering, Jungwon University, Goesan-eup, Chungbuk, Korea

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  • Woo Young Sim equal contributor,

    equal contributor Contributed equally to this work with: Sang-Hyug Park, Woo Young Sim

    Affiliations: Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Byoung-Hyun Min,

    Affiliations: Department of Orthopeadic Surgery, Medical School, Ajou University, Youngtong-Gu, Suwon, Korea, Department of Molecular Science and Technology, Ajou University, Youngtong-Gu, Suwon, Korea

    X
  • Sang Sik Yang,

    Affiliation: Department of Electrical and Computer Engineering, Ajou University, Youngtong-Gu, Suwon, Korea

    X
  • Ali Khademhosseini,

    Affiliations: Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

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  • David L. Kaplan mail

    david.kaplan@tufts.edu

    Affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, United States of America

    X
  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0046689

About the Authors

Sang-Hyug Park, David L. Kaplan
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, United States of America
Sang-Hyug Park
Department of Biomedical Engineering, Jungwon University, Goesan-eup, Chungbuk, Korea
Woo Young Sim, Ali Khademhosseini
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Woo Young Sim, Ali Khademhosseini
Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Byoung-Hyun Min
Department of Orthopeadic Surgery, Medical School, Ajou University, Youngtong-Gu, Suwon, Korea
Byoung-Hyun Min
Department of Molecular Science and Technology, Ajou University, Youngtong-Gu, Suwon, Korea
Sang Sik Yang
Department of Electrical and Computer Engineering, Ajou University, Youngtong-Gu, Suwon, Korea
Ali Khademhosseini
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

Corresponding Author

Email: david.kaplan@tufts.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SP WS BM SY AK DK. Performed the experiments: SP WS. Analyzed the data: SP WS BM SY AK DK. Contributed reagents/materials/analysis tools: SP WS. Wrote the paper: SP WS BM SY AK DK.