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Research Article

The Clinical Significance of MiR-148a as a Predictive Biomarker in Patients with Advanced Colorectal Cancer

  • Masanobu Takahashi,

    Affiliation: Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America

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  • Miriam Cuatrecasas,

    Affiliation: Pathology Department, Centro de Diagnóstico Biomédico (CDB), Tumour Bank, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Biobank Hospital Clínic, University of Barcelona, Barcelona, Spain

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  • Francesc Balaguer,

    Affiliation: Gastroenterology Department, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS, University of Barcelona, Barcelona, Spain

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  • Keun Hur,

    Affiliation: Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America

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  • Yuji Toiyama,

    Affiliation: Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America

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  • Antoni Castells,

    Affiliation: Gastroenterology Department, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS, University of Barcelona, Barcelona, Spain

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  • C. Richard Boland mail,

    rickbo@baylorhealth.edu (CRB); ajay.goel@baylorhealth.edu (AG)

    Affiliation: Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America

    X
  • Ajay Goel mail

    rickbo@baylorhealth.edu (CRB); ajay.goel@baylorhealth.edu (AG)

    Affiliation: Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046684

About the Authors

Masanobu Takahashi, Keun Hur, Yuji Toiyama, C. Richard Boland, Ajay Goel
Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America
Miriam Cuatrecasas
Pathology Department, Centro de Diagnóstico Biomédico (CDB), Tumour Bank, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Biobank Hospital Clínic, University of Barcelona, Barcelona, Spain
Francesc Balaguer, Antoni Castells
Gastroenterology Department, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS, University of Barcelona, Barcelona, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MT FB KH YT AG. Performed the experiments: MT MC. Analyzed the data: MT YT. Contributed reagents/materials/analysis tools: AC FB YT. Wrote the paper: MT MC FB AC CRB AG.