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Research Article

Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins

  • Àlex Bayés mail,

    seth.grant@ed.ac.uk (SG); ABayesP@santpau.cat (AB)

    Affiliations: Molecular Physiology of the Synapse Laboratory, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, UAB, Barcelona, Catalonia, Spain, Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, United Kingdom, Department of Clinical Neuroscience. School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Mark O. Collins,

    Affiliation: Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

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  • Mike D. R. Croning,

    Affiliations: Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, United Kingdom, Department of Clinical Neuroscience. School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Louie N. van de Lagemaat,

    Affiliations: Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, United Kingdom, Department of Clinical Neuroscience. School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Jyoti S. Choudhary,

    Affiliation: Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

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  • Seth G. N. Grant mail

    seth.grant@ed.ac.uk (SG); ABayesP@santpau.cat (AB)

    Affiliations: Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, United Kingdom, Department of Clinical Neuroscience. School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046683

About the Authors

Àlex Bayés
Molecular Physiology of the Synapse Laboratory, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, UAB, Barcelona, Catalonia, Spain
Àlex Bayés, Mike D. R. Croning, Louie N. van de Lagemaat, Seth G. N. Grant
Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, United Kingdom
Àlex Bayés, Mike D. R. Croning, Louie N. van de Lagemaat, Seth G. N. Grant
Department of Clinical Neuroscience. School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom
Mark O. Collins, Jyoti S. Choudhary
Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB MOC JSC SG. Performed the experiments: AB MOC MDRC LNVDL. Analyzed the data: AB MOC MDRC LNVDL. Wrote the paper: AB MOC MDRC LNVDL SG.