Advertisement
Research Article

Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases

  • Frederic Derbre equal contributor,

    equal contributor Contributed equally to this work with: Frederic Derbre, Beatriz Ferrando, Mari Carmen Gomez-Cabrera

    Affiliation: Laboratory “Movement Sport and Health Sciences”, University Rennes 2-ENS Cachan, Rennes, France

    X
  • Beatriz Ferrando equal contributor,

    equal contributor Contributed equally to this work with: Frederic Derbre, Beatriz Ferrando, Mari Carmen Gomez-Cabrera

    Affiliation: Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain

    X
  • Mari Carmen Gomez-Cabrera equal contributor,

    equal contributor Contributed equally to this work with: Frederic Derbre, Beatriz Ferrando, Mari Carmen Gomez-Cabrera

    Affiliation: Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain

    X
  • Fabian Sanchis-Gomar,

    Affiliation: Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain

    X
  • Vladimir E. Martinez-Bello,

    Affiliation: Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain

    X
  • Gloria Olaso-Gonzalez,

    Affiliation: Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain

    X
  • Ana Diaz,

    Affiliation: UCIM, Faculty of Medicine, University of Valencia, Valencia, Spain

    X
  • Arlette Gratas-Delamarche,

    Affiliation: Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain

    X
  • Miguel Cerda,

    Affiliation: Department of Pathology, University of Valencia, Valencia, Spain

    X
  • Jose Viña mail

    jose.vina@uv.es

    Affiliation: Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain

    X
  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046668

About the Authors

Beatriz Ferrando, Mari Carmen Gomez-Cabrera, Fabian Sanchis-Gomar, Vladimir E. Martinez-Bello, Gloria Olaso-Gonzalez, Arlette Gratas-Delamarche, Jose Viña
Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain
Frederic Derbre
Laboratory “Movement Sport and Health Sciences”, University Rennes 2-ENS Cachan, Rennes, France
Ana Diaz
UCIM, Faculty of Medicine, University of Valencia, Valencia, Spain
Miguel Cerda
Department of Pathology, University of Valencia, Valencia, Spain

Corresponding Author

Email: jose.vina@uv.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JV AG-D. Performed the experiments: FD BF MCG-C GO-G FS-G AD. Analyzed the data: VEM-B. Contributed reagents/materials/analysis tools: MC. Wrote the paper: JV MCG-C.