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Research Article

Measles Virus Glycoprotein-Based Lentiviral Targeting Vectors That Avoid Neutralizing Antibodies

  • Sabrina Kneissl mail,

    Sabrina.Kneissl@pei.de (SK); Christian.Buchholz@pei.de (CJB)

    Affiliation: Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany

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  • Tobias Abel,

    Affiliation: Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany

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  • Anke Rasbach,

    Affiliation: Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany

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  • Julia Brynza,

    Affiliation: Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany

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  • Jürgen Schneider-Schaulies,

    Affiliation: Institute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany

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  • Christian J. Buchholz mail

    Sabrina.Kneissl@pei.de (SK); Christian.Buchholz@pei.de (CJB)

    Affiliation: Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany

    X
  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0046667

About the Authors

Sabrina Kneissl, Tobias Abel, Anke Rasbach, Julia Brynza, Christian J. Buchholz
Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany
Jürgen Schneider-Schaulies
Institute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany

Corresponding Authors

Competing Interests

SK and CJB are listed as inventors in an international Patent Cooperation Treaty/European patent application (PCT/EP2007/008384 “Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening”) assigned to the Paul-Ehrlich-Institut, which includes as claims the generation of targeted lentiviral vectors. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SK CJB. Performed the experiments: SK TA JB. Analyzed the data: SK TA AR CJB. Contributed reagents/materials/analysis tools: JS-S. Wrote the paper: SK CJB.